Lời bình cho các bài báo mới và có chất lượng
Cái nà do vietbio đưa ra, tôi đã đọc và thấy rất hay. Lại may mắn cái chả hiểu sao vô đăng ký lại được nên post ra đây để những ai quan tâm coi chơi. Chả biết cho vào mục nào nên để tạm ở đây, dontcry chuyển giúp tôi ra mục phù hợp nhé.
Đầu tiên là top10
1. F1000 Factor 10.4
http://www.ncbi.nlm.nih.gov/entrez/...ds=15790847&dopt=Abstract&holding=f1000,hulib
Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles.
Colosimo PF, Hosemann KE, Balabhadra S, Villarreal G, Dickson M, Grimwood J, Schmutz J, Myers RM, Schluter D, Kingsley DM
Science 2005 Mar 25 307(5717):1928-33
Trudy Mackay
North Carolina State University, United States of America
DEVELOPMENTAL BIOLOGY
Comments
Trudy Mackay
North Carolina State University, United States of America
DEVELOPMENTAL BIOLOGY
New Finding
This paper provides one answer to two longstanding and open questions regarding the basis of adaptive evolution: is the basis of adaptive evolution due to single genes with large effects or multiple quantitative trait loci (QTL) with individually small effects; and if the former, is the repeated evolution of the same adaptation attributable to multiple independent mutations in the same gene, a single mutation event harbored at low frequency in multiple populations, or mutations in different genes? While marine threespine sticklebacks have extensive bony armour, freshwater populations have repeatedly evolved a reduction in this armour. Colosimo et al. show that the reduction in armour is largely attributable to a single QTL with large effect, with minor modifier loci. High resolution mapping and positional cloning of the major QTL revealed the candidate gene to be Ectodysplasin (Eda). Thus, adaptive evolution can at least sometimes have a simple genetic basis. Further, the same Eda haplotype was found in several North American and European freshwater populations, while a different Eda haplotype was observed in a Japanese population. Thus, at least two independent mutations in the same gene led to the same adaptive phenotype, and there is a single genetic basis for the evolution of reduced armour in the North American and European populations.
Evaluated 3 May 2005
Richard Harrison
Cornell University, United States of America
GENOMICS & GENETICS
This paper uses positional cloning and linkage disequilibrium mapping to identify the gene responsible for major differences in armor plate patterning between marine and freshwater sticklebacks. The authors provide gene genealogical data to support the hypothesis that parallel selection of alleles at the Ectodysplasin locus (Eda) has led to repeated evolution of low-plated phenotypes in freshwater environments. By constructing transgenic fish containing the mouse version of the Eda gene, the authors provide additional support for a role for this gene in the parallel evolution of the novel phenotype. This paper is an elegant exemplar of what can be done using modern genomic approaches to document the genetic and molecular basis of an important evolutionary transition driven by natural selection.
Evaluated 26 Apr 2005
Tony Long
University of California, Irvine, United States of America
GENOMICS & GENETICS
Another brilliant piece of work by the Kingsley group on the evolution of armor plating in stickleback fish. The authors positionally clone a gene that leads to an adaptive reduction in body armor in numerous stickleback populations. Cloning this gene was an incredibly difficult piece of work, and represents one of only a handful of examples where we now have insight into the molecular basis of morphological evolution. It was always thought that the stickleback in different watersheds have independently evolved a reduction in armor plating (in fact this character is a textbook example of repeated convergent evolution). Very surprisingly, this paper shows that many different populations harbor the same recessive allele leading to armor reduction that apparently can migrate between populations in marine morphs if covered by the dominant allele. Time to rewrite the textbooks!
Evaluated 25 Apr 2005
Patricia Simpson
University of Cambridge, United Kingdom
DEVELOPMENTAL BIOLOGY
This study presents new hope to all those working in nonmodel systems that, with heroic effort, one can actually identify with some confidence the gene(s) involved in natural adaptations. The authors used QTL mapping, sequencing, and transgenics to indicate that the same Ectodysplasin alleles were fixed in disparate populations causing parallel evolution of armor plating. There is some indication an independent mutation may also have caused the same phenotype in an isolated population, but the evidence for this secondary result was significantly weaker. Hence, it appears repeated selection on the standing genetic variation already present in marine ancestors caused parallel evolution of armor plating in these sticklebacks.
Evaluated 18 Apr 2005
Detlef Weigel
Max Planck Institute for Developmental Biology, Germany
PLANT BIOLOGY
This paper sets a new standard in the identification of adaptive variants found in nature. The authors not only use QTL (quantitative trait locus) cloning to identify a locus controlling plate morphology in natural populations of sticklebacks, but also show that the same rare haplotype present in marine forms was selected during the formation of plateless freshwater forms, where it became fixed. This happened apparently independently all over the world. This paper has almost everything; the only important experiment missing was transformation of a functional natural allele into a background with a reduced-function allele.
Evaluated 6 Apr 2005
Cái nà do vietbio đưa ra, tôi đã đọc và thấy rất hay. Lại may mắn cái chả hiểu sao vô đăng ký lại được nên post ra đây để những ai quan tâm coi chơi. Chả biết cho vào mục nào nên để tạm ở đây, dontcry chuyển giúp tôi ra mục phù hợp nhé.
Đầu tiên là top10
1. F1000 Factor 10.4
http://www.ncbi.nlm.nih.gov/entrez/...ds=15790847&dopt=Abstract&holding=f1000,hulib
Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles.
Colosimo PF, Hosemann KE, Balabhadra S, Villarreal G, Dickson M, Grimwood J, Schmutz J, Myers RM, Schluter D, Kingsley DM
Science 2005 Mar 25 307(5717):1928-33
Trudy Mackay
North Carolina State University, United States of America
DEVELOPMENTAL BIOLOGY
Comments
Trudy Mackay
North Carolina State University, United States of America
DEVELOPMENTAL BIOLOGY
New Finding
This paper provides one answer to two longstanding and open questions regarding the basis of adaptive evolution: is the basis of adaptive evolution due to single genes with large effects or multiple quantitative trait loci (QTL) with individually small effects; and if the former, is the repeated evolution of the same adaptation attributable to multiple independent mutations in the same gene, a single mutation event harbored at low frequency in multiple populations, or mutations in different genes? While marine threespine sticklebacks have extensive bony armour, freshwater populations have repeatedly evolved a reduction in this armour. Colosimo et al. show that the reduction in armour is largely attributable to a single QTL with large effect, with minor modifier loci. High resolution mapping and positional cloning of the major QTL revealed the candidate gene to be Ectodysplasin (Eda). Thus, adaptive evolution can at least sometimes have a simple genetic basis. Further, the same Eda haplotype was found in several North American and European freshwater populations, while a different Eda haplotype was observed in a Japanese population. Thus, at least two independent mutations in the same gene led to the same adaptive phenotype, and there is a single genetic basis for the evolution of reduced armour in the North American and European populations.
Evaluated 3 May 2005
Richard Harrison
Cornell University, United States of America
GENOMICS & GENETICS
This paper uses positional cloning and linkage disequilibrium mapping to identify the gene responsible for major differences in armor plate patterning between marine and freshwater sticklebacks. The authors provide gene genealogical data to support the hypothesis that parallel selection of alleles at the Ectodysplasin locus (Eda) has led to repeated evolution of low-plated phenotypes in freshwater environments. By constructing transgenic fish containing the mouse version of the Eda gene, the authors provide additional support for a role for this gene in the parallel evolution of the novel phenotype. This paper is an elegant exemplar of what can be done using modern genomic approaches to document the genetic and molecular basis of an important evolutionary transition driven by natural selection.
Evaluated 26 Apr 2005
Tony Long
University of California, Irvine, United States of America
GENOMICS & GENETICS
Another brilliant piece of work by the Kingsley group on the evolution of armor plating in stickleback fish. The authors positionally clone a gene that leads to an adaptive reduction in body armor in numerous stickleback populations. Cloning this gene was an incredibly difficult piece of work, and represents one of only a handful of examples where we now have insight into the molecular basis of morphological evolution. It was always thought that the stickleback in different watersheds have independently evolved a reduction in armor plating (in fact this character is a textbook example of repeated convergent evolution). Very surprisingly, this paper shows that many different populations harbor the same recessive allele leading to armor reduction that apparently can migrate between populations in marine morphs if covered by the dominant allele. Time to rewrite the textbooks!
Evaluated 25 Apr 2005
Patricia Simpson
University of Cambridge, United Kingdom
DEVELOPMENTAL BIOLOGY
This study presents new hope to all those working in nonmodel systems that, with heroic effort, one can actually identify with some confidence the gene(s) involved in natural adaptations. The authors used QTL mapping, sequencing, and transgenics to indicate that the same Ectodysplasin alleles were fixed in disparate populations causing parallel evolution of armor plating. There is some indication an independent mutation may also have caused the same phenotype in an isolated population, but the evidence for this secondary result was significantly weaker. Hence, it appears repeated selection on the standing genetic variation already present in marine ancestors caused parallel evolution of armor plating in these sticklebacks.
Evaluated 18 Apr 2005
Detlef Weigel
Max Planck Institute for Developmental Biology, Germany
PLANT BIOLOGY
This paper sets a new standard in the identification of adaptive variants found in nature. The authors not only use QTL (quantitative trait locus) cloning to identify a locus controlling plate morphology in natural populations of sticklebacks, but also show that the same rare haplotype present in marine forms was selected during the formation of plateless freshwater forms, where it became fixed. This happened apparently independently all over the world. This paper has almost everything; the only important experiment missing was transformation of a functional natural allele into a background with a reduced-function allele.
Evaluated 6 Apr 2005
